The Saracens’ second row leads a starting side in the non-cap international that features fellow England international Marcus Smith at full-back with the Red Rose pair of Alex Mitchell and Fin Smith the half-backs.
Ireland’s Tadhg Furlong will have the chance to prove his fitness after struggling with a calf injury that ruled him out of Leinster’s United Rugby Championship final victory over the Bulls.
Furlong is included on a bench that also features Ireland hooker Ronan Kelleher.
“Congratulations to Maro Itoje ahead of leading out the Lions for the first time. It’s a truly special moment and one that very few players ever get to experience,” said head coach Andy Farrell.
“Maro has led the group well during our time in Portugal and then Dublin this week. This is also our first opportunity to show what the 2025 Lions are about and what we want to stand for as a team.”
A strong Argentina team will be captained by hooker Julian Montoya, six days after the hooker featured in the Leicester side that lost the English Premiership final to Bath.
Santiago Carreras is at full-back with Tomas Albornoz at fly-half, while Saracens flanker Juan Martin Gonzalez is in a back row also featuring the experienced Pablo Matera.
The 30-year-old Itoje, previously appointed as Lions captain for the upcoming three-Test tour of Australia, skippered England to second place in this year’s Six Nations.
The Lions, made up of leading players from England, Scotland, Ireland and Wales, play their first Test in Australia on July 19 at Brisbane’s Suncorp Stadium. (AFP)