The benchmark Hang Seng Index rose 291 points, or 1.2 percent, to 25,042 on turnover of HK$202.73 billion.
The tech index rose 17 points, or 0.4 percent, to 4,423 while the China enterprises index gained 114 points, or 1.4 percent, to 8,339.
On the mainland, the benchmark Shanghai Composite Index ended up 38 points, or 0.97 percent, at 3,949.
The Shenzhen Component Index was 89 points, or 0.65 percent, higher at 13,730.
The combined turnover of the Shanghai and Shenzhen indices was 2.03 trillion yuan, down from 2.08 trillion yuan on Friday.
Medical services, cellular immunotherapy and recombinant protein stocks were among the top gainers, while precious metals and photolithography equipment shares led the declines.
The ChiNext Index gained 26 points, or 0.8 percent, to close at 3,399.
Tech shares gained after Vice Premier He Lifeng and US Treasury Secretary Scott Bessent concluded talks in New York on Sunday, with the US side proposing a new AI safety notification mechanism ahead of the Xi-Trump summit between Wednesday and Friday.
Market expectations for the meeting are tempered, but the main focus is whether the leaders will signal an extension to a trade truce struck last year.
“Overall, we think both sides will seek to maintain relative stability in US-China relations, although a broad bilateral agreement appears unlikely,” analysts at Goldman Sachs said in a note.
Among other gainers, the real estate sector surged 6.9 percent and the defence sector added 2 percent.
Healthcare rose 3.6 percent after a Reuters report that the US is working on rules for pharmaceutical companies investing in China that would likely preserve their ability to strike most licensing deals for Chinese drugs.
In Seoul, the Kospi ended up 113 points, or 1.65 percent, at 7,007, led by gains in chipmakers after upbeat domestic export data and a rally in US semiconductor stocks on Friday.
The Nikkei was closed for a holiday on Monday. (Reuters/Xinhua)
