Guardiola guided City to 20 trophies, including six Premier League titles and the club’s only Champions League, over the past 10 seasons.
Aston Villa’s visit to the Etihad on Sunday will be his final match in charge, although he is set to continue working for the City Football Group as a global ambassador.
“What a time we have had together!” Guardiola said in a club statement.
“Don’t ask me the reasons I’m leaving. There is no reason, but deep inside, I know it’s my time.
“Nothing is eternal, if it was, I would be here. Eternal will be the feeling, the people, the memories, the love I have for my Manchester City.”
News of the Catalan’s impending departure was first reported on Monday.
At that point, the former Barcelona and Bayern Munich boss was tight-lipped on his future as City missed out on the Premier League title to Arsenal 24 hours later.
The timing of Guardiola’s exit comes with the outcome of an investigation into more than 100 alleged breaches by City of financial regulations still to be released.
First charged by the Premier League in February 2023, an independent commission hearing concluded in December 2024 with the case hanging over City’s achievements on the pitch ever since. (AFP)