In his first-ever meeting with Norrie, Sinner won 81 percent of his first-serve points, and 63 percent of the points behind his second delivery on his way to notching a 25th consecutive victory at Masters 1000 level and 20th on tour.
Sinner, who is bidding to reach the semi-finals for the first time in the Spanish capital, will next face 19-year-old Jodar in what is expected tobe an explosive last-eight showdown.
The Italian world number one is just the second man in series history to win his first 20 Masters 1000 matches of the season, joining Novak Djokovic, who achieved that feat twice, in 2011 and 2015.
Later in the day, Jodar’s dream run on home soil continued with a convincing 7-5, 6-0 thumping of world number 66 Vit Kopriva.
The Madrid-born wild card advanced to the biggest quarter-final of his young career, and improved to 12-1 on clay so far this season. (AFP)