Daniel Farke’s men will return to the top division if Sheffield United fail to win at second-placed Burnley in the evening kick-off.
Burnley will be promoted along with Leeds if they beat Sheffield United.
Leeds, who last played in the Premier League in the 2022/23 season, suffered the agony of defeat to Southampton in last season’s Championship play-off final at Wembley.
The Yorkshire club – three-time English champions – are now near certainties to gain promotion after humbling Stoke at Elland Road.
Dutch forward Piroe, who had not scored since late February, returned to form with a vengeance, celebrating a hat-trick in the 20th minute.
Junior Firpo made it four, and Piroe, the club’s leading scorer this season, netted his fourth goal shortly before half-time.
The game was already long over as a contest but Wilfried Gnonto nodded a sixth goal in the 59th minute.
Leeds wobbled from the start of March, winning just one in six games, raising fears that they would again have to settle for a place in the play-offs.
But they have now won their past four league games and may have just hours to wait until their promotion is confirmed. (AFP)
